Workshop Details
Protein Electrostatics (In-person participation)
06/06/2022 - 06/10/2022
Meeting Description:

Electrostatic forces govern many key biochemical processes, including all of energy transduction (e.g. catalysis, proton transport, electron transfer, ion homeostasis, etc). Despite 30 years of focused efforts to elucidate the structural basis of electrostatic effects in proteins, this remains a very challenging problem. It has become increasingly clear that polarization, structural relaxation, charge fluctuations, dielectric breakdown, water penetration, and coupling between ionizable sites, all contribute to the stabilization of charge inside proteins. A true multi-scale approach that considers processes ranging from quantum mechanical effects to conformational fluctuations in biological time scales will be needed to make progress in this field. Many novel computational methods have been developed recently that can improve our ability to treat electrostatic effects. However, each of these approaches considers a limited range of factors. Furthermore, developments have been hampered by the lack of experimental data that can provide clear benchmarks for validating the different approaches. The purpose of this workshop will be to bring together experimentalists, theorists and simulators with shared interests in electrostatic effects in water-soluble and membrane proteins. One aim of this workshop will be to identify the critical areas where experiments are needed to obtain physical insight to guide improvements to computational models and data to benchmark these models. Another aim will be to compare and contrast the strengths and weaknesses of different simulation frameworks used to calculate equilibrium constants for ion binding, pKa values, redox Ems, and the effects of pH and salt on conformational transitions. The ultimate goal is to lower the barriers for collaboration amongst and between theory, computation, and experiment.


We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.

TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on TSRC's website. Feel free to contact TSRC's staff to help with any planning and/or coordinating care.

Meeting Venue:

Telluride Intermediate School
725 W Colorado Ave, Telluride CO 81435
Click Here for Directions

Meeting Details:

Workshop Price: $ 449.00
Early Bird Lodging Discount Available Until: 01/31/2022

A $100.00 discount is applied to your lodging cost when you register before 01/31/2022.

Cancellation Policy: Cancellation Policy: Once a credit card has been charged, cancelled registrations will be subject to a cancellation fee. We will process registration fees beginning on January 15th, 2022. If a payment of registration fees has been processed, a $25 cancellation fee will be retained from a registration refund. Lodging fee payments will be processed 60 days prior to arrival, and a $100 cancellation fee will apply if cancellations occur after a lodging fee payment is completed. TSRC can only guarantee a refund for the remaining lodging fees if requested prior to the cancellation deadline that is specific to each lodging provider. TSRC always recommends that participants purchase travel insurance to protect against unforeseen, last-minute travel plan changes.

Protein Electrostatics (In-person participation) Registered Meeting Participants:
Participant Organization
Damjanovic, Ana Johns Hopkins University
Grubmueller, Helmut Max Planck Institute for multidisciplinary Sciences
Gunner, Marilyn Physics Dept CCNY
Kisor, Kyle University of California, San Francisco
Kougentakis, Christos University of California, San Francisco
Miller, Anne-Frances University of Kentucky
Mobley, David L. University of California, Irvine
Mroginski, Maria Andrea Technische Universität Berlin
Romero Moreno, Ricardo University of Notre Dame
Sandoval-Perez, Gloria Angelica UCSF
Vant, John Wyatt Arizona State University
Webb, Lauren The University of Texas at Austin
White, Katharine University of Notre Dame

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
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