Workshop Details
Phase Separation in Biology and Disease
03/16/2020 - 03/20/2020
Meeting Description:

The phenomenon of liquid-liquid phase separation (LLPS) has emerged in the last 10 years as a ubiquitous mechanism for organizing biopolymers within condensed, often liquid-like, bodies in cells to perform a dizzying array of biological processes. For example, phase separation is known to mediate nucleolar organization and ribosome biogenesis, cell fate determination in early development, activity-dependent protein translation in neurons, super enhancer-dependent gene expression, gene silencing, endocytosis, T cell receptor signaling, and many other processes too numerous to mention. Further, aberrant phase separation caused by gene mutations, or through altered protein regulation, is associated with a plethora of human diseases, including neurodegenerative disorders and a variety of cancers. This workshop will focus on several cutting-edge topics, as follows:

- Biological roles of phase separation, both cytoplasmic and nuclear
- Links between aberrant phase separation and disease
- Strategies to therapeutically modulate phase separation.

TSRC workshops are very small meetings (<25 attendees) which feature in depth discussion of topics at the interfaces of physics, chemistry and biology. All attendees will present a ~40 minute lecture and are encouraged to stay for the entire time. Meetings will be held in the mornings, allowing for afternoon discussions and outdoor activities, including skiing, snowshoeing, snowmobile driving, sledding, walking, etc. Discussions continue over ad hoc large and small group dinners.

We strive for gender and career-stage balance amongst attendees. In addition to attracting academic scientists, an important goal is to engage scientists from biotech companies focused on "drugging LLPS" that are beginning to emerge (e.g., Dewpoint Therapeutics, https://www.dewpointtherapeutics.com/) and others.

Notes:

The registration fee includes breakfast on each workshop day. In lieu of the traditional TSRC picnic on Wednesday night, TSRC will contribute $20/person toward a group dinner event, which is currently being planned. Sponsorship funds will further support the group dinner.

We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering. If you have registered for a meeting you were not invited to, you may be subject to a $100 fee.

TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. There is information on childcare and family activities at https://www.telluridescience.org/travel/families. Please contact Cindy Fusting at cindy@telluridescience.org with any questions or for assistance in coordinating care.

Meeting Venue:

Wilkinson Public Library
100 West Pacific Ave Telluride, CO 81435
Click Here for Directions

Meeting Details:

Workshop Price: $ 390.00
Early Bird Lodging Discount Available Until: 11/15/2019

A $100.00 discount is applied to your lodging cost when you register before 11/15/2019.

Cancellation Policy: All cancelled registrations are subject to a $100 Cancellation Fee. TSRC can only guarantee a refund for the balance of fees and lodging charges paid when a refund is requested prior to the Cancellation Deadline that is specific to each workshop, which in this case is 02/16/2020. TSRC always recommends that participants purchase travel insurance to protect against unforeseen, last-minute travel plan changes.

Registered Meeting Participants:
Participant Organization Arrival Information Departure Information Interested in Sharing Transportation?
Klein, isaac Dana-Farber Cancer Institute
Kriwacki, Richard St. Jude Children's Research Hospital 3/15
3/21
Reinkemeier, Christopher Dieter European Molecular Biology Laboratory 3/15
3/21
Strader, Lucia Washington University in St. Louis 3/15
3/21

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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