Workshop Details
Emerging Methodologies for Paramagnetic NMR and Dynamic Nuclear Polarization in Biological and Inorganic Materials
08/05/2019 - 08/08/2019
Meeting Description:

This workshop will provide a form to describe and discuss recent breakthroughs in sensitivity enhancement of nuclear magnetic resonance (NMR) methods through dynamic nuclear polarization (DNP), and use of paramagnetic doping agents. NMR is arguably the most information-rich spectroscopic technique, and has broad applications for materials science medicine and biology, yet it is hampered by low sensitivity. Dynamic nuclear polarization experiments have demonstrated potential to attain dramatic enhancements for the sensitivity of NMR detection. DNP experiments involve observation of samples containing paramagnetic agents, either doped or naturally occurring. Irradiation of the ESR lines corresponding to these sites can result in favorable non-equilibrium changes in the polarization of the nuclear spin systems. Under favorable conditions, quite dramatic sensitization of the NMR systems, up to x600 can be observed. Despite the potentially transformative nature of DNP, and the rapidly growing popularity of these experiments, the methods and mechanisms of DNP are not very well understood, and many open questions must be explored to develop DNP as a general and robust technique that enables structural characterization.

This area is at an intersection of several fields of spectroscopy, for example NMR of paramagnetic materials, EPR, and theories of spin diffusion and spin temperature, and therefore progress in this field will benefit from discussions among these distinct sub-disciplines. NMR of paramagnetic species is itself an emerging and challenging area of spectroscopy, and offers expanding opportunities for structural investigation via a wealth of structural and electronic information contained in the NMR observables and the possibilities of exploiting paramagnetic relaxation for sensitivity enhancement.

This workshop will be unique in bringing together scientists who work on the development and applications of NMR, EPR, paramagnetic NMR and dynamic nuclear polarization methodologies and their applications to biological and inorganic materials; there currently is no such venue where this promising and expanding area of spectroscopy is discussed. The workshop will include presentations by the participants, highlighting emerging techniques, and convening in-depth discussions and brain-storming sessions on the future directions of the field.

Notes:

We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering. If you have registered for a meeting you were not invited to, you may be subject to a $100 fee.

TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on TSRC's website. Feel free to contact TSRC's staff to help with any planning and/or coordinating care.

Five breakfasts, the TSRC BBQ picnic, and a group dinner at the Village Table is included in the registration price.

Supporting Files:

NMR.Schedule_final.pdf
Meeting Venue:

Telluride Intermediate School
725 West Colorado Ave Telluride, CO 81435

Emerging Methodologies for Paramagnetic NMR and Dynamic Nuclear Polarization in Biological and Inorganic Materials Registered Meeting Participants:
Participant Organization
Bennati, Marina Max Planck Institute for Biophysical Chemistry
Corzilius, Bjoern Goethe University Frankfurt
Frederick, Kendra UTSouthwestern
Gan, Zhehong NHMFL
Goldfarb, Daniella Weizmann Institute of Science
Griffin, Robert Guy MIT
Gronenborn, Angela M. University of Pittsburgh
Han, Songi UC Santa Barbara
Ishii, Yoshitaka Tokyo Institute of Technology
Jeschke, Gunnar ETH Zürich
Lelli, Moreno University of Florence
Leskes, Michal Department of Materials and Interfaces, Weizmann Institute of Science
Matsuki, Yoh Osaka University
Oschkinat, Hartmut Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Prisner, Thomas Goethe University Frankfurt
Rosay, Melanie Bruker BioSpin
Sergeyev, Ivan Bruker Biospin Corp.
Thurber, Kent NIH

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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