Workshop Details
Cystic Fibrosis: Ecology, Evolution, and Eradication
08/07/2017 - 08/11/2017
Meeting Description:

The development and application of culture-independent approaches (i.e. high throughput sequencing of bacterial and viral community DNA) has generated a profound shift in our understanding of chronic respiratory infections in cystic fibrosis (CF) patients. We now recognize the importance of polymicrobial interactions, environmental conditions and evolutionary adaptations in the progression of CF disease. Yet, a lack of ecological perspective has limited the translation of bench research into effective therapeutic strategies. For example, how do you describe the response of a bacterial community to an environmental condition, without direct measurements of these conditions in vivo? Recently, applications of integrated �omics� approaches � genomics, transcriptomics, proteomics, and metabolomic profiling � have shed light on the ecological dynamics of CF bacterial communities, though many outstanding questions remain. This will be the 4th bi-annual meeting of the TSRC CF workshop, which began in 2009 with the goal of building theoretical models of CF lung physiology to identify ecological and evolutionary instabilities. We will explore ecological and evolutionary approaches to modeling the CF lung environment and the microbiota that resides there, with the ultimate goal of devising more effective clinical therapy. In addition to a review of the last few TSRC CF meetings, talks from both basic scientists and clinicians will emphasize new tools and hypotheses about the CF bacterial ecosystem and its relation to disease progression. But as with all good Telluride workshops, the aim is to do research on-site. One-hour talks have been known to last an entire afternoon due to intensive probing from the audience. Come prepared to give chalk talks and/or show slides and plots about your work� anything that you feel is important!

Notes:

Notes:
GOAL: IDENTIFY WEAKNESSES IN THE CYSTIC FIBROSIS ECOSYSTEM THAT CAN BE THERAPUTICALLY EXPLOITED...



Possible Products

A) Models of CF lung that help us identify evolutionary and ecological instabilities

B) Identify missing datasets that are critical for managing CF as an ecosystem

C) Exchange information amongst biologists, clinicians, and mathematicians



Tentative Talks / Discussion Sessions:
Paul Rainey (Massey University & Max Planck Institute for Evolutionary Biology)
Forest Rohwer (SDSU)
Peter Salamon (SDSU)
Doug Conrad (UCSD)
Robert Quinn (SDSU)
Yan Wei Lim (SDSU)
Katrine Whiteson (UC Irvine)
Ryan Hunter (Minnesota)
Megan Bergkessel (Caltech)
Rachel Whittaker (Illinois)
Kirk Harris (Colorado)
Edith Zemanick (Colorado)
Hara Levy (Medical College Wisconsin)
Matt Wargo (Vermont)
Bryan Williams (Minnesota)
Brandie Wagner (Colorado)

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people.

Meeting Venue:

Telluride Intermediate School
725 West Colorado Ave Telluride CO 81435

Cystic Fibrosis: Ecology, Evolution, and Eradication Registered Meeting Participants:
Participant Organization
Bailey, Barbara San Diego State University
Bean, Heather Arizona State University
Binder, Kelsey University of Minnesota
Bojanowski, Christine University of California, San Diego
Bomberger, Jennifer University of Pittsburgh
Caverly, Lindsay University of Michigan
Cobian Guemes, Ana Georgina San Diego State University
Conrad, Douglas UC San Diego
Felts, Ben San Diego State University
Gallagher, Tara UC Irvine
Hahn, Andrea Children’s National Medical Center
Harris, Kirk University of Colorado
Hunter, Ryan University of Minnesota
Limoli, Dominique Geisel School of Medicine at Dartmouth
LiPuma, John J. University of Michigan
Lucas, Sarah University of Minnesota
Rohwer, Forest San Diego State University
Silveira, Cynthia San Diego State University
Tuemmler, Burkhard Medizinische Hochschule Hannover
Wagner, Brandie university of colorado denver
Wargo, Matthew University of Vermont
Whiteson, Katrine University of California, Irvine
Widder, Stefanie Medical University of Vienna

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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