Workshop Details
Protein Electrostatics
06/26/2017 - 06/30/2017
Meeting Description:

Electrostatic forces govern many key biochemical processes, including all of energy transduction (e.g. catalysis, proton transport, electron transfer, ion homeostasis, etc). Despite 30 years of focused efforts to elucidate the structural basis of electrostatic effects in proteins, this remains a very challenging problem. It has become increasingly clear that polarization, structural relaxation, charge fluctuations, dielectric breakdown, water penetration, and coupling between ionizable sites, all contribute to the stabilization of charge inside proteins. A true multi-scale approach that considers processes ranging from quantum mechanical effects to conformational fluctuations in biological time scales will be needed to make progress in this field. Many novel computational methods have been developed recently that can improve our ability to treat electrostatic effects. However, each of these approaches considers a limited range of factors. Furthermore, developments have been hampered by the lack of experimental data that can provide clear benchmarks for validating the different approaches. The purpose of this workshop will be to bring together experimentalists, theorists and simulators with shared interests in electrostatic effects in water-soluble and membrane proteins. One aim of this workshop will be to identify the critical areas where experiments are needed to obtain physical insight to guide improvements to computational models and data to benchmark these models. Another aim will be to compare and contrast the strengths and weaknesses of different simulation frameworks used to calculate equilibrium constants for ion binding, pKa values, redox Ems, and the effects of pH and salt on conformational transitions. The ultimate goal is to lower the barriers for collaboration amongst and between theory, computation, and experiment.

Notes:

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people.

Meeting Venue:

Telluride Intermediate School
725 W Colorado Ave, Telluride CO 81435
Click Here for Directions

Meeting Details:

Early Bird Price: $ 290.00
Last Date that Early Bird Price is Available: 01/31/2017
Regular Price: $ 390.00
Cancellation Policy: TSRC can only guarantee refunds on registration fees and lodging charges prior to the "cancellation deadline" date of your specific workshop, which in this case is 05/26/2017. Please take out travel insurance if you may have to cancel after this date.

Registered Meeting Participants:
Participant Organization Arrival Information Departure Information Interested in Sharing Transportation?
Alexov, Emil Clemson University 6/25
7/1
Baptista, Antonio TSRC 6/24
7/1
Beckstein, Oliver Arizona State University 6/25
6/30
Damjanovic, Ana Johns Hopkins University 6/25
6/30
Donnini, Serena University of Jyvaskyla 6/25
7/1
Garcia-Moreno, Bertrand Johns Hopkins University 6/25
7/1
Garrido Ruiz, Diego UCSF 6/25
7/1
Y
Groenhof, Gerrit University of Jyvaskyla 6/25
7/1
Y
Gunner, Marilyn City College of New York 6/24
7/2
Gutman, Hemi Tel aviv University 6/25
6/30
Kurnikova, Maria Carnegie Mellon University 6/25
6/30
Y
Lund, Mikael Lund university 6/25
7/2
Machuqueiro, Miguel Faculdade de Ciências, Universidade de Lisboa 6/25
7/1
Y
Nachliel, Esther Tel- Aviv University 6/25
7/1
Nielsen, Jens Erik Novozymes 6/25
6/30
Raleigh, Daniel P Stony Brook University 6/25
6/30
Tsfadia, Yossi Tel Aviv University 6/25
7/1
Webb, Lauren The University of Texas at Austin 6/25
7/3
White, Katharine University of California San Francisco 6/25
7/1

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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