Workshop Details
Cystic Fibrosis: Ecology, Evolution, and Eradication
07/29/2013 - 08/02/2013
Meeting Description:

New approaches to cystic fibrosis (CF) have recently become available in both the experimental and the theoretical arenas. In the experimental arena, large-scale metagenomics and breath gas analysis on sputum samples has revealed many more species present than traditional culturing methods. MRI scans of CF promise location specific growth data observable often and giving some of the same information that only CT scans could provide. These techniques have made the dynamics of the CF lung as an ecosystem accessible to observation. Such observation needs guidance from theory. The workshop will explore ecological and evolutionary approaches to modeling the CF lung and their application to devising an optimal treatment regimen. The 2009 TSRC workshop on this theme focused on building mathematical models. In addition to a quick review of the last TSRC (1 to 2 days maximum) we also plan to present new data, as well as, new techniques, and more importantly how to put this data into a model using FBA/EBA net flux approaches complemented by functional components all to explain exhalation data. But as with all good Telluride workshops, the aim is to do research on-site. One-hour talks last two hours due to intensive probing from the audience. Come prepared to give chalk talks and/or PowerPoint about your work...especially things that you think are important.

Notes:

Notes:
GOAL: IDENTIFY WEAKNESSES IN THE CYSTIC FIBROSIS ECOSYSTEM THAT CAN BE THERAPUTICALLY EXPLOITED...




Possible Products

A) Models of CF lung that help us identify evolutionary and ecological instabilities

B) Identify missing datasets that are critical for managing CF as an ecosystem

C) Exchange information amongst biologists, doctors, and mathematicians



Possible talks/discussion sessions:

Paul Rainey - Evolutionary instabilities and the CF lung

Forest Rohwer - Microbial ecology and relationship to CF lung

Peter Salamon - Physiological models and optimal disease treatments

Doug Conrad - Clinicians view of treating CF

Katrine Whiteson- CF breath gas analysis
Robert Quinn – New culturing techniques and Omics analysis of CF community
Yan We Lim - Viral communities in the CF sputum

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people.

Meeting Venue:

Telluride Intermediate School
725 West Colorado Ave Telluride C0 81435

Registered Meeting Participants:
Participant Organization Arrival Information Departure Information Interested in Sharing Transportation?
Bailey, Barbara San Diego State University 7/28
8/2
Bergkessel, Megan California Institute of Technology 7/29
8/2
Chia, Nicholas Mayo Clinic 7/28
8/2
Conrad, Douglas UC San Diego 7/28
8/3
Delhaes, Laurence Lille2 University 7/28
8/2
Delhaes, Laurence [2nd Reservation] Lille2 University 7/27
7/28
Felts, Ben San Diego State University 7/28
8/4
Harris, Kirk University of Colorado 7/28
8/4
Hunter, Ryan California Institute of Technology 7/28
8/2
Jamil, Kamran UCSD
Lim, Yan Wei San Diego State University 7/28
8/2
Quinn, Robert SDSU Research Foundation 7/28
8/2
Rainey, Paul New Zealand Institute for Advanced Study 7/28
8/4
Y
Salamon, Peter San Diego State University 7/14
8/3
Segall, Anca San Diego State University 7/27
8/2
Sullivan, James Vertex Pharmaceuticals
Theilmann, Rebecca University of California, San Diego
Wagner, Brandie University of Colorado 7/28
8/2
Whiteson, Katrine SDSU 7/28
8/2
Y

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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