Enhanced sampling is one of the most important issues in computational biophysics research. In recent years, there have been some significant progresses in algorithmic development for systems of interest to both physicists and biophysicists. Those methods are related in their mathematical foundations, but also different in their applications. Typical examples include recent development on various generalized-ensemble-based sampling methods including those using Wang-Landau sampling scheme. The impact on studying complex biological macromolecules of these advanced simulation methods has just begun to emerge. In many cases, such as in free energy simulation of biomolecular processes, those new methods have shown to be transforming in terms of speed of calculation and efficiency of sampling. Thus, we believe that it will be timely to put together a Telluride workshop for the top-players to exchange ideas and to discuss future directions.