Workshop Details
Water Structure, Dynamics and Thermodynamics in Biology
06/25/2023 - 06/29/2023
Meeting Description:

BRIEF DESCRIPTION: This workshop focuses on water at biomolecular surfaces including proteins, nucleic acids, and lipid bilayers. A central theme is to obtain a quantitative picture of the impact of water on mechanisms, structure, function and transport that is rooted in a molecular, microscopic and mechanistic perspective. While the importance of water as a solvent for biomolecular processes has been realized for decades, new experimental and theoretical developments provide revealing insights into water dynamics and water-mediated interactions on the molecular scale. For example, this allows us to decode the context-dependence of the hydrophobic effect and other water-mediated interactions.

This workshop aims to spark discussions that lead to new discoveries and fruitful collaborations by assembling a diverse group of experimentalists and theoreticians from around the globe, whose work has transformed our understanding of water in biomolecular systems. The common goal of this Telluride Science workshop will be to find convergence in our understanding of biological hydration, a topic that has been rife with controversy and disagreements. Our means to find common understanding will be through sharing data and simulation methods, and the comparison of different theoretical, and experimental, approaches on common systems and questions.

WHY NOW? The development of accurate protein structure prediction algorithms and cryo-electron microscopy are game changers in the field of structural biology. Consequently, the accessibility of atomistic structures of biomolecules and biomolecular complexes has dramatically increased. However, a missing element in this picture is the molecular environment in which the proteins are found in nature. This includes structural water molecules in proteins, hydrophobic interactions in aqueous solutions that stabilize native protein structures, and the embedding of proteins in lipid bilayers. Interactions with the molecular environment critically contribute to the free energy surface on which biomolecular processes take place, including molecular recognition, conformational transitions, and enzymatically catalyzed reactions.

Many advances in our understanding of biomolecules are driven by computational and experimental tools that interrogate their interactions with water and lipids. New spectroscopic techniques reveal the heterogeneous structure and dynamics of water hydrating proteins and lipid membranes, while novel computational models and simulation models provide increasingly detailed descriptions of the underlying microscopic interactions and their thermodynamic consequences. The goal of this workshop is to foster the exchange of new cutting-edge results and ideas in this area.

Notes:

IMPORTANT: Participants should be aware that this workshop runs Sunday through Thursday. The 4th of July lodging rates will go into effect on the night of Thursday the 29th. To avoid the rate increase, you should depart on the evening of the 29th. If your flight out of Montrose does not leave until Friday the 30th, we suggest eating dinner in Telluride on the night of the 29th, taking the shuttle to Montrose after dinner, and staying at the Hampton Inn (970-547-4120) next to the airport. You will receive a discount at the Hampton Inn by saying you are a TSRC scientist.

We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.

Telluride Science is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on Telluride Science's website. Feel free to contact Telluride Science's staff to help with any planning and/or coordinating care.

Meeting Venue:

Telluride Intermediate School
721 W Colorado Ave Telluride, CO 81435
Click Here for Directions

Meeting Details:

Workshop Price: $ 449.00
Early Bird Lodging Discount Available Until: 02/01/2023

A $100.00 discount is applied to your lodging cost when you register before 02/01/2023.

Cancellation Policy: Cancellation Policy: Once a credit card has been charged, cancelled registrations will be subject to a cancellation fee. We will process registration fees beginning on January 15th, 2022. If a payment of registration fees has been processed, a $25 cancellation fee will be retained from a registration refund. Lodging fee payments will be processed 60 days prior to arrival, and a $100 cancellation fee will apply if cancellations occur after a lodging fee payment is completed. TSRC can only guarantee a refund for the remaining lodging fees if requested prior to the cancellation deadline that is specific to each lodging provider. TSRC always recommends that participants purchase travel insurance to protect against unforeseen, last-minute travel plan changes.

Telluride Science Research Center
Post Office Box 2429, Telluride CO 81435
Tel: + 970.708.4426
Email: info@telluridescience.org
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