YAP/TAZ and TEAD: At the Crossroads of Cancer
06/25/2023 - 06/29/2023
Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.
The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.
2021 Eaton Foundation Fellow:
IMPORTANT: Participants should be aware that this workshop runs Sunday through Thursday. The 4th of July lodging rates will go into effect on the night of Thursday the 29th. To avoid the rate increase, you should depart on the evening of the 29th. If your flight out of Montrose does not leave until Friday the 30th, we suggest eating dinner in Telluride on the night of the 29th, taking the shuttle to Montrose after dinner, and staying at the Hampton Inn (970-547-4120) next to the airport. You will receive a discount at the Hampton Inn by saying you are a TSRC scientist.
We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.
Telluride Science is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on Telluride Science's website. Feel free to contact Telluride Science's staff to help with any planning and/or coordinating care.
Workshop Price: $ 0.00
Early Bird Lodging Discount Available Until: 02/01/2023
A $100.00 discount is applied to your lodging cost when you register before 02/01/2023.
Cancellation Policy: Once a credit card has been charged, cancelled registrations will be subject to a cancellation fee. We will process registration fees beginning on January 15th, 2022
. If a payment of registration fees has been processed, a $25 cancellation fee will be retained from a registration refund. Lodging fee payments will be processed 60 days prior to arrival
, and a $100 cancellation fee will apply if cancellations occur after a lodging fee payment is completed. TSRC can only guarantee a refund for the remaining lodging fees if requested prior to the cancellation deadline that is specific to each lodging provider. TSRC always recommends that participants purchase travel insurance to protect against unforeseen, last-minute travel plan changes.